Ryan Reynolds’ Hilarious Meltdown Over Deadpool VR Game Casting Will Leave You in Stitches

The Deadpool VR Game has taken the internet by storm, and Ryan Reynolds is stealing the spotlight with his side-splitting reaction to being replaced by Neil Patrick Harris as the voice of Deadpool.

Unveiled by @Marvel at Summer Game Fest 2025, this Meta Quest 3 exclusive promises chaotic fun, but it’s Reynolds’ mock outrage that’s got everyone talking. From a Doogie Howser parody to witty jabs, here’s everything you need to know about his viral response and the game itself.

What’s the Deal with the Deadpool VR Game?

Marvel’s Deadpool VR Game, set to launch later in 2025, is a high-octane, first-person action title developed by Twisted Pixel and Oculus Studios in collaboration with Marvel Games. Exclusively for Meta Quest 3 and 3S, it features an original story where Deadpool, pulled into Mojoworld, signs a shady contract for riches and battles Marvel villains with his signature parkour and ultraviolent combat. Think punching enemies with grenades or using your severed arm as a weapon—classic Deadpool chaos in VR.

Unlike previous Deadpool games, this one swaps Ryan Reynolds for Neil Patrick Harris as the Merc with a Mouth. The reveal trailer, dropped at Summer Game Fest, showcased Harris’ snarky delivery, breaking the fourth wall with jabs like mocking Spider-Man’s PlayStation exclusives. Fans are hyped, but Reynolds’ reaction has turned the announcement into a viral sensation.

Why Did Ryan Reynolds “Over-React” to the Casting?

Reynolds, who’s played Deadpool in four films, didn’t take the recasting lying down—or so he’d have us believe. In a YouTube video titled “Ryan Over-Reacts to Marvel’s Deadpool VR,” he channels his inner comedian with a parody of Neil Patrick Harris’ iconic Doogie Howser, M.D. role.

Dressed in a lab coat and glasses, Reynolds types on a retro computer, journaling about the “buttholes” who “stole” his signature role, complete with exaggerated angst and a cameo from Doogie Howser co-star Robyn Lively.

The video, likely part of the Deadpool VR Game’s marketing strategy, is pure Reynolds—sassy, meta, and dripping with Deadpool’s humor. Fans on X have called it “10/10,” with comments praising the deep-cut Doogie Howser reference and Reynolds’ fake typing skills. One user quipped, “I’ve finally learned how to type on the keyboard because of this,” while others lauded the ad’s nod to ‘90s nostalgia.

How Are Fans Reacting to Reynolds’ Video?

The internet is eating up Reynolds’ reaction, with X posts buzzing about his comedic genius. @ComicBook kicked off the hype, sharing the video and noting Harris’ casting, while @InsiderGamingIG called it a “classic response.” @GeekNative posted about the “hilarious” clip hot on the heels of the red-band trailer, and @screenrant highlighted Reynolds’ playful jab at Harris “stealing” Deadpool.

The video’s racked up hundreds of likes and comments on Reddit’s OculusQuest subreddit, with fans joking about Reynolds’ “up-and-coming actor” status and the ad’s millennial appeal.

Some fans expressed mixed feelings about Harris voicing the Deadpool VR Game. While many agree Harris nails the snark, others feel Reynolds is Deadpool. Still, the consensus is that Reynolds’ video is a masterclass in turning a recasting into marketing gold, keeping fans excited for the game’s release.

What Makes the Deadpool VR Game So Exciting?

Beyond the casting drama, the Deadpool VR Game is shaping up to be a wild ride. The trailer promises comic-book visuals, brutal combat, and Deadpool’s trademark humor.

Players can dual-wield pistols, swing katanas, or get creative with dismemberment—like shoving a villain’s face into a propeller. The game’s VR format lets you “be Deadpool,” with moments like controlling his body as a decapitated head or watching a new arm regrow.

Twisted Pixel’s Dan Bullock emphasized capturing Deadpool’s fourth-wall-breaking essence, making VR the perfect medium for his antics.

Early hands-on impressions from IGN and UploadVR rave about the game’s immersive violence and fun. Executive producer Jody Coglianese revealed Marvel encouraged Twisted Pixel to push boundaries, suggesting moves like angle-specific sword actions.

With battles against iconic and obscure Marvel villains, the Deadpool VR Game is poised to be a standout title for Meta Quest users.

Will Reynolds Return as Deadpool in the Future?

While Harris takes the VR spotlight, Reynolds isn’t done with Deadpool. He recently teased an “ensemble” project, possibly tied to the MCU’s Avengers: Secret Wars, though nothing’s confirmed.

His commitment to the character, from redeeming Deadpool after X-Men Origins: Wolverine to the blockbuster Deadpool & Wolverine, assures fans he’ll return to the big screen. For now, his Deadpool VR Game reaction keeps him front and center, proving he’s as much a marketing genius as he is an actor.

Why Is This Reaction Going Viral?

Reynolds’ video isn’t just funny—it’s a testament to his knack for staying relevant. By leaning into Deadpool’s meta humor and poking fun at himself, he’s turned a potential PR hiccup into a win for the Deadpool VR Game.

The Doogie Howser spoof resonates with fans who grew up in the ‘90s, while the video’s short, punchy format is perfect for social media. X users like @JayFlemming and @zingodude have shared it with laughing emojis, calling it “funny and wrong” in the best way.

This is Reynolds doing what he does best: keeping Deadpool’s spirit alive, even when he’s not voicing the game.

Some Closing Thoughts:

Ryan Reynolds’ reaction to the Deadpool VR Game is the gift that keeps on giving. His Doogie Howser-inspired meltdown is a hilarious nod to Neil Patrick Harris’ casting, proving that even when he’s “replaced,” Reynolds remains the heart of Deadpool.

With the game set to deliver bloody, immersive fun on Meta Quest 3, the buzz around this VR title is only growing.

Whether you’re a die-hard Deadpool fan or just here for Reynolds’ antics, this viral moment is a must-watch.

Keep an eye out for the Deadpool VR Game later this year—and don’t miss Reynolds stealing the show, one snarky video at a time.